On the heels of the previous post, here they go again…

Computer algorithm developed by TAU researchers identifies genes that could be transformed to stop the aging process

Restricting calorie consumption is one of the few proven ways to combat aging. Though the underlying mechanism is unknown, calorie restriction has been shown to prolong lifespan in yeast, worms, flies, monkeys, and, in some studies, humans.

Now Keren Yizhak, a doctoral student in Prof. Eytan Ruppin‘s laboratory at Tel Aviv University‘s Blavatnik School of Computer Science, and her colleagues have developed a computer algorithm that predicts which genes can be “turned off” to create the same anti-aging effect as calorie restriction. The findings, reported in Nature Communications, could lead to the development of new drugs to treat aging. Researchers from Bar-Ilan University collaborated on the research.

“Most algorithms try to find drug targets that kill cells to treat cancer or bacterial infections,” says Yizhak. “Our algorithm is the first in our field to look for drug targets not to kill cells, but to transform them from a diseased state into a healthy one.”

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